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Antibody
Engineering

Antibody Engineering

Engineering Towards Developability

From affinity and specificity to stability, expression, and aggregation, we engineer antibodies with the properties needed for successful clinical development.

Let ‘s Take Your Antibody to the Next Level
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  • Sequence Optimization
  • Developability Assessment
  • Computational Design
  • Wet-Lab Proven

Engineering and Lead Optimization

Optimize Antibodies for Your Drug Development Pipeline

YUMAB® offers advanced bioinformatics and engineering technologies to improve and optimize existing antibody candidates (also from other sources, e.g. hybridoma). The art of antibody engineering involves a combination of in vitro and AI-assisted in silico technologies to optimize clinically relevant properties.

YuCARE

Placing Priority on Developability, Safety and Efficacy

YUMAB’s YuCARE™ is our integrated AI-driven in silico toolbox for advanced lead candidate selection, antibody engineering, and sequence optimization – designed to generate high-quality candidates for clinical development.

By combining state-of-the-art AI and bioinformatic prediction with rigorous experimental wet-lab validation, we bridge computational design and real-world performance. Instead of testing only individual variants, we design and screen large, highly diverse antibody libraries—ranging from millions to billions of AI-guided sequences—to maximize the probability of identifying optimal candidates.

YuCARE enables the generation of AI-guided CDR mutagenesis libraries for affinity maturation that are simultaneously optimized for developability and rapidly validated within our high-throughput experimental workflow.

In addition, we collaborate with external AI partners by providing advanced wet-lab screening and validation capabilities to accelerate antibody discovery and engineering programs.

Placing priority on developability, safety, and efficacy
Evaluate your antibody optimization potential
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Expert Answers

When is antibody engineering needed?
Most antibodies identified through our platform can be used directly without any additional engineering. In some cases, however, optimization may be required to adapt an antibody to a specific application. Depending on the requirements, this may include improving affinity, stability, specificity, developability, or adapting the antibody to a different format.
We can optimize a range of antibody properties, including affinity, specificity, stability, expression, solubility, pH sensitivity, and developability. The optimization strategy is tailored to the desired profile of the antibody and its intended application.
We can work with a broad range of antibody formats, including IgG, Fab, scFv, VHH, bispecific antibodies, and other customized formats. The format can be selected or engineered according to the intended application.
Yes. YUMAB can work with existing antibody sequences or leads, regardless of whether they were generated internally or through another discovery platform. We can apply engineering, humanization, format conversion, or optimization strategies based on the starting molecule and project objectives.
 
YUMAB combines rational protein engineering, computational design, and experimental screening to optimize antibody candidates. Depending on the project, we use sequence-based analysis, structure-guided design, mutagenesis, library generation, and display-based screening to identify variants with improved properties such as affinity, specificity, stability, and developability.

Talk to a scientist

Dr. Phillip Kuhn
VP Services & Operations

Discuss your Project

We typically reply within 1-2 business days.