Rare antibodies with unusual structures and ultra-long CDRs have the potential to bind to difficult-to-access epitopes (e.g., GPCRs, ion channels), and thus offer a unique mode of action. But since they are considered non-developable, they are often excluded from rationally designed antibody libraries or neglected in developability-driven AI selections.
This application note demonstrates how tailored antibody engineering at YUMAB transofrms non-ideal antibodies into therapeutic leads.
