Immunogenic target discovery

YUMAB provides services for the identification of novel immunogenic targets for vaccine or diagnostic assay development.

YUMAB’s unique pHORF technology generates new target/antigen gene libraries covering all possible open reading frames (ORFs) from genomic DNA of infectious pathogens. Identification of immunogenic target proteins is achieved by functional screening against serum antibodies of infected or immunized human donors or animals. Our technology covers all possible protein products of pathogens and bypasses the limitations of cDNA libraries from cultivated pathogens expressing different genes than during infection.

Identification of immunogenic targets/antigens can be directly linked to YUMAB’s human antibody generation pipeline for the development of diagnostic assays or therapeutic antibodies.